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A separate 2025 review in SAGE Journals also evaluates the broader musculoskeletal evidence base

& Pennefather, P

doi: 10.3390/ijms26168075 45 SharmaAAnandSKSinghNDwivediUNKakkarP

Many active ingredients in TCM present issues like poor stability, solubility, and difficulty crossing the BBB, which restrict their use in treating depression effectively

-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level

Employing a higher value for the threshold factor k would impose a more stringent selection criterion, preferentially identifying reactions with the strongest linear correlation (R) between flux and predictive contribution